In the other 3 groups (NMO-Ab/MOG-Ab, NMO-Ab/MOG-Ab, and NMO-Ab/MOG-Ab), visual acuity did not change significantly (P = 0.53, 0.42, and 0.45, respectively). In the NMO-Ab/MOG-Ab group, visual acuity improved significantly (P < 0.0001).
Three (50%) of 6 eyes of patients seropositive for both antibodies did not respond to corticosteroid pulse therapy and plasmapheresis, and visual acuity remained unchanged. Ten (43%) of 23 patients were seronegative for both antibodies. Six (26%) of 23 patients were seropositive for both NMO-Ab and MOG-Ab. MOG-Ab seropositivity was defined by comparing with MOG-Ab level obtained from 8 healthy normal subjects.Įleven (47%) of 23 ON patients were NMO-Ab seropositive, while 8 (34%) of the 23 patients were MOG-Ab seropositive. At presentation, serum NMO-Ab was measured by immunofluorescence using HEK 293 cells transfected with AQP4-GFP, and anti-MOG1-125 antibody was measured by enzyme-linked immunosorbent assay. Alternative products to Anti-MOG Antibody (A83178) (2) A35668.
People with anti-MOG related NMO similarly have episodes of transverse myelitis and optic neuritis, but recovery after attacks appears to be. Anti-MOG Antibody (A83178) staining (0.03µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane). Thirty-three eyes of 23 patients with ON were studied. In people with NMO who test negative for anti-AQP4 antibodies, up to a third may be positive for auto-antibodies directed against a component of myelin called myelin oligodendrocyte glycoprotein (MOG). We investigated the relationship between NMO antibody (NMO-Ab) and anti-MOG antibody (MOG-Ab) and potential in patients with ON for recovery of vision. MOG antigen is currently considered as a cause of optic neuritis (ON) associated with MS because immunization with MOG antigen derived from oligodendrocytes induces murine ON with myelitis. Myelin oligodendrocyte glycoprotein (MOG) is well known as the causative protein of multiple sclerosis (MS). These reagents are now offered in bundles with MOG Antibody (D-2) ( see ordering information below).Damage to astrocytes by anti-aquaporin-4 antibody (AQP4-Ab), also known as NMO antibody, has been implicated as the cause of neuromyelitis optica. m-IgG Fc BP-HRP, m-IgG 1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MOG Antibody (D-2) for WB and IHC(P) applications.
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